medicine

The Immortal Life of Henrietta Lacks

Amazon Best Books of the Month, February 2010: From a single, abbreviated life grew a seemingly immortal line of cells that made some of the most crucial innovations in modern science possible. And from that same life, and those cells, Rebecca Skloot has fashioned in The Immortal Life of Henrietta Lacks a fascinating and moving story of medicine and family, of how life is sustained in laboratories and in memory. Henrietta Lacks was a mother of five in Baltimore, a poor African American migrant from the tobacco farms of Virginia, who died from a cruelly aggressive cancer at the age of 30 in 1951. A sample of her cancerous tissue, taken without her knowledge or consent, as was the custom then, turned out to provide one of the holy grails of mid-century biology: human cells that could survive--even thrive--in the lab. Known as HeLa cells, their stunning potency gave scientists a building block for countless breakthroughs, beginning with the cure for polio. Meanwhile, Henrietta's family continued to live in poverty and frequently poor health, and their discovery decades later of her unknowing contribution--and her cells' strange survival--left them full of pride, anger, and suspicion. For a decade, Skloot doggedly but compassionately gathered the threads of these stories, slowly gaining the trust of the family while helping them learn the truth about Henrietta, and with their aid she tells a rich and haunting story that asks the questions, Who owns our bodies? And who carries our memories? --Tom Nissley

Honestly, I can't imagine a better tale.

A detective story that's at once mythically large and painfully intimate.

Just the simple facts are hard to believe: that in 1951, a poor black woman named Henrietta Lacks dies of cervical cancer, but pieces of the tumor that killed her--taken without her knowledge or consent--live on, first in one lab, then in hundreds, then thousands, then in giant factories churning out polio vaccines, then aboard rocket ships launched into space. The cells from this one tumor would spawn a multi-billion dollar industry and become a foundation of modern science--leading to breakthroughs in gene mapping, cloning and fertility and helping to discover how viruses work and how cancer develops (among a million other things). All of which is to say: the science end of this story is enough to blow one's mind right out of one's face.

But what's truly remarkable about Rebecca Skloot's book is that we also get the rest of the story, the part that could have easily remained hidden had she not spent ten years unearthing it: Who was Henrietta Lacks? How did she live? How she did die? Did her family know that she'd become, in some sense, immortal, and how did that affect them? These are crucial questions, because science should never forget the people who gave it life. And so, what unfolds is not only a reporting tour de force but also a very entertaining account of Henrietta, her ancestors, her cells and the scientists who grew them.

The book ultimately channels its journey of discovery though Henrietta's youngest daughter, Deborah, who never knew her mother, and who dreamt of one day being a scientist.

As Deborah Lacks and Skloot search for answers, we're bounced effortlessly from the tiny tobacco-farming Virginia hamlet of Henrietta's childhood to modern-day Baltimore, where Henrietta's family remains. Along the way, a series of unforgettable juxtapositions: cell culturing bumps into faith healings, cutting edge medicine collides with the dark truth that Henrietta's family can't afford the health insurance to care for diseases their mother's cells have helped to cure.

Rebecca Skloot tells the story with great sensitivity, urgency and, in the end, damn fine writing. I highly recommend this book. --Jad Abumrad

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Her name was Henrietta Lacks, but scientists know her as HeLa. She was a poor Southern tobacco farmer who worked the same land as her slave ancestors, yet her cells—taken without her knowledge—became one of the most important tools in medicine. The first “immortal” human cells grown in culture, they are still alive today, though she has been dead for more than sixty years. If you could pile all HeLa cells ever grown onto a scale, they’d weigh more than 50 million metric tons—as much as a hundred Empire State Buildings. HeLa cells were vital for developing the polio vaccine; uncovered secrets of cancer, viruses, and the atom bomb’s effects; helped lead to important advances like in vitro fertilization, cloning, and gene mapping; and have been bought and sold by the billions.

Yet Henrietta Lacks remains virtually unknown, buried in an unmarked grave.

Now Rebecca Skloot takes us on an extraordinary journey, from the “colored” ward of Johns Hopkins Hospital in the 1950s to stark white laboratories with freezers full of HeLa cells; from Henrietta’s small, dying hometown of Clover, Virginia—a land of wooden slave quarters, faith healings, and voodoo—to East Baltimore today, where her children and grandchildren live and struggle with the legacy of her cells.

Henrietta’s family did not learn of her “immortality” until more than twenty years after her death, when scientists investigating HeLa began using her husband and children in research without informed consent. And though the cells had launched a multimillion-dollar industry that sells human biological materials, her family never saw any of the profits. As Rebecca Skloot so brilliantly shows, the story of the Lacks family—past and present—is inextricably connected to the dark history of experimentation on African Americans, the birth of bioethics, and the legal battles over whether we control the stuff we are made of.

Over the decade it took to uncover this story, Rebecca became enmeshed in the lives of the Lacks family—especially Henrietta’s daughter Deborah, who was devastated to learn about her mother’s cells. She was consumed with questions: Had scientists cloned her mother? Did it hurt her when researchers infected her cells with viruses and shot them into space? What happened to her sister, Elsie, who died in a mental institution at the age of fifteen? And if her mother was so important to medicine, why couldn’t her children afford health insurance? 
          
Intimate in feeling, astonishing in scope, and impossible to put down, The Immortal Life of Henrietta Lacks captures the beauty and drama of scientific discovery, as well as its human consequences.

Hypothyroidism Type 2: The Epidemic

An astonishing book revealing the cause and successful treatment for the plague of illnesses affecting western civilization; including obesity, heart attacks, depression, diabetes, strokes, headaches, chronic fatigue, and many more.

In Dr. Starr's description of Type 2 Hypothyroidism, he presents overwhelming evidence showing a majority of Americans suffer this illness, which is due to environmental and hereditary factors.

Laboratory testing used to diagnose hypothyroidism is completely inadequate, and current treatment for hypothyroidism is ineffective.

Groundbreaking research shows how persistent environmental toxins prevent thyroid and other hormones from working properly.

This book will lead you to understanding more about your health than anything you have ever read.

The China Study: The Most Comprehensive Study of Nutrition Ever Conducted and the Startling Implications for Diet, Weight Loss and Long-term Health

Tarascon Pocket Pharmacopoeia 2010 Classic Shirt-Pocket Edition (Tarascon Pocket Pharmacopoeia: Classic Shirt-Pocket Edition)

Tarascon Pocket Pharmacopoeia® 2010 Classic Shirt-Pocket Edition continues its tradition as the leading portable drug reference packed with vital drug information to help clinicians make better decisions at the point of care. Each edition is meticulously peer-reviewed by experts and is now available in multiple formats. It details typical drug dosing (both FDA approved and off-label uses), available trade and generic formulations, metabolism, safety in pregnancy and lactation, relative drug pricing information, Canadian trade names, and an herbal & alternative therapies section. Multiple tables supplement the drug content, including opioid equivalency, emergency drug infusions, cardiac dysrhythmia protocols, pediatric drug dosing, and much more! Save time and improve patient care with the 2010 Tarascon Pocket Pharmacopoeia. New to the 2010 Edition: New HIV and H1N1 (Swine Flu) drug coverage and dosing requirements. New H1N1 table with CDC recommendations on the H1N1 vaccine and influenza antiviral drugs. Fully updated to include hundreds of newly approved drugs, drug indications, forms, pricing, black box warnings and more. Essential diseases underlined for easier navigation. More concise organization for faster lookup. Original Pharmacopoeia formatted tables based on customer feedback. Includes FREE 6 month subscription to the Tarascon Pocket Pharmacopoeia Web Edition.

The Poisoner's Handbook: Murder and the Birth of Forensic Medicine in Jazz Age New York

Amazon Exclusive: Author Deborah Blum's Top Ten Poisons

On a recent radio show, I heard myself telling the host "And carbon monoxide is such a good poison.” We both started laughing--there’s just something about a Pulitzer-prize winning journalist waxing enthusiastic about something so lethal. But then he became curious--“Why?” he asked. “Why do you like it so much?”

These days, as I travel the country talking about The Poisoner’s Handbook, I’m frequently asked that question or variations on it. What’s your favorite poison? What’s the perfect poison? The answer to the latter is that it doesn’t exist--except in the plots of crime novels.

But in reality, poisons really are fascinatingly wicked chemical compounds and many of them have fascinating histories as well. Just between us, then, here’s a list of my personal favorites.

1. Carbon Monoxide (really)--It’s so beautifully simple (just two atoms--one of carbon, one of oxygen) and so amazingly efficient a killer. There’s a story I tell in the book about a murder syndicate trying to kill an amazingly resilient victim. They try everything from serving him poison alcohol to running over him with a car. But in the end, it’s carbon monoxide that does him in.

2. Arsenic--This used to be the murderer’s poison of poisons, so commonly used in the early 19th century that it was nicknamed “the inheritance powder”. It’s also the first poison that forensic scientists really figured out how to detect in a corpse. And it stays in the body for centuries, which is why we keep digging up historic figures like Napoleon or U.S. President Zachary Taylor to check their remains for poison.

3. Radium--I love the fact that this rare radioactive element used to be considered good for your health. It was mixed into medicines, face creams, health drinks in the 1920s. People thought of it like a tiny glowing sun that would give them its power. Boy, were they wrong. The two scientists in my book, Charles Norris and Alexander Gettler, proved in 1928 that the bones of people exposed to radium became radioactive--and stayed that way for years.

4. Nicotine--This was the first plant poison that scientists learned to detect in a human body. Just an incredible case in which a French aristocrat and her husband decided to kill her brother for money. They actually stewed up tobacco leaves in a barn to brew a nicotine potion. And their amateur chemical experiments inspired a very determined professional chemist to hunt them down.

5. Chloroform--Developed for surgical anesthesia in the 19th century, this rapidly became a favorite tool of home invasion robbers. If you read newspapers around the turn of the 20th century, they’re full of accounts of people who answered a knock on the door, only to be knocked out by a chloroform soaked rag. One woman woke up to find her hair shaved off--undoubtedly sold for the lucrative wig trade.

6. Mercury--In its pure state, mercury appears as a bright silver liquid, which scatters into shiny droplets when touched. No wonder it’s nicknamed quicksilver. People used to drink it as a medicine more than 100 years ago. No, they didn’t drop dead. Those silvery balls just slid right through them. Mercury is much more poisonous if it’s mixed with other chemicals and can be absorbed by the body directly. That’s why methylmercury in fish turns out to be so risky a contaminant.

7. Cyanide--One of the most famous of the homicidal poisons and--in my opinion--not a particularly good choice. Yes, it’s amazingly lethal--a teaspoon of the pure stuff can kill in a few minutes. But it’s a violent and obvious death. In early March, in fact, an Ohio doctor was convicted of murder for putting cyanide in his wife’s vitamin supplements.

8. Aconite--A heart-stoppingly deadly natural poison. It forms in ornamental plants that include the blue-flowering monkshood. The ancient Greeks called it “the queen of poisons” and considered it so evil that they believed that it derived from the saliva of Cerberus, the three-headed dog guarding the gates of hell.

9. Silver--Swallowing silver nitrate probably won’t kill you but if you do it long enough it will turn you blue. One of my favorite stories (involving a silver bullet) concerns the Famous Blue Man of Barnum and Bailey’s Circus who was analyzed by one of the heroes of my book, Alexander Gettler.

10. Thallium--Agatha Christie put this poison at the heart of one of her creepiest mysteries, The Pale Horse, and I looked at it terms of a murdered family in real life. An element discovered in the 19th century, it’s a perfect homicidal poison--tasteless and odorless--except for one obvious giveaway--the victim’s hair falls out as a result of the poisoning!

Now that I’ve written this list, I realize I could probably name ten more. But I don’t want to scare you.

--Deborah Blum

Pulitzer Prize-winning science writer Deborah Blum follows New York City's first forensic scientists to discover a fascinating Jazz Age story of chemistry and detection, poison and murder.

Deborah Blum, writing with the high style and skill for suspense that is characteristic of the very best mystery fiction, shares the untold story of how poison rocked Jazz Age New York City. In The Poisoner's Handbook Blum draws from highly original research to track the fascinating, perilous days when a pair of forensic scientists began their trailblazing chemical detective work, fighting to end an era when untraceable poisons offered an easy path to the perfect crime.

Drama unfolds case by case as the heroes of The Poisoner's Handbook-chief medical examiner Charles Norris and toxicologist Alexander Gettler-investigate a family mysteriously stricken bald, Barnum and Bailey's Famous Blue Man, factory workers with crumbling bones, a diner serving poisoned pies, and many others. Each case presents a deadly new puzzle and Norris and Gettler work with a creativity that rivals that of the most imaginative murderer, creating revolutionary experiments to tease out even the wiliest compounds from human tissue. Yet in the tricky game of toxins, even science can't always be trusted, as proven when one of Gettler's experiments erroneously sets free a suburban housewife later nicknamed "America's Lucretia Borgia" to continue her nefarious work.

From the vantage of Norris and Gettler's laboratory in the infamous Bellevue Hospital it becomes clear that killers aren't the only toxic threat to New Yorkers. Modern life has created a kind of poison playground, and danger lurks around every corner. Automobiles choke the city streets with carbon monoxide; potent compounds, such as morphine, can be found on store shelves in products ranging from pesticides to cosmetics. Prohibition incites a chemist's war between bootleggers and government chemists while in Gotham's crowded speakeasies each round of cocktails becomes a game of Russian roulette. Norris and Gettler triumph over seemingly unbeatable odds to become the pioneers of forensic chemistry and the gatekeepers of justice during a remarkably deadly time. A beguiling concoction that is equal parts true crime, twentieth-century history, and science thriller, The Poisoner's Handbook is a page-turning account of a forgotten New York.

First Aid for the USMLE Step 1, 2010 (First Aid USMLE)

The 20th edition of the world’s #1 selling medical review book!

Trust two decades of experience for the most effective USMLE Step 1 preparation possible

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INSIDER ADVICE FOR STUDENTS FROM STUDENTS

The Trigger Point Therapy Workbook: Your Self-Treatment Guide for Pain Relief, Second Edition

The first edition of this workbook is regarded as a classic in its field, and was the first book to introduce trigger point therapy to the general public as a self-care tool for alleviating chronic pain caused by a variety of conditions, including arthritis, back pain, carpal tunnel syndrome, fibromyalgia, headache, muscle ache, and repetitive strain injuries. As the author makes clear, all such conditions are related to lack of oxygen in exhausted or injured muscle tissue. Trigger point therapy has been used for decades by doctors, pain specialists, and massage therapists to quickly stimulate the flow of oxygen and promote rapid pain reduction. This book makes the same techniques available to the general public with instructions that are easy to follow, and abetted by an extensive collection of charts and corresponding illustrations.

The author’s interest in trigger point therapy began when he used it to successfully treat his frozen shoulder. Since that time, he has dedicated himself to teaching others the same techniques. That dedication is obvious throughout his writing and the care he takes to make the therapy understandable to the lay public. Also included in this new edition is updated information that should be of great interest to pain specialists and bodyworkers, as well as useful instruction in a variety of relaxation techniques. Overall, this book is an excellent self-care resource for anyone interested in pain relief.--Larry Trivieri Jr.

Trigger point therapy is one of the most intriguing and fastest-growing bodywork styles in the world. Medical doctors, chiropractors, physical therapists, and massage therapists are all beginning to use this technique to relieve formerly undiagnosable muscle and joint pain—conditions that studies have shown to be the cause of nearly 25 percent of all doctor visits. The technique involves applying short, repeated massage strokes to trigger points, tiny contraction knots in muscle tissue where restricted circulation and lack of oxygen cause referred pain. Trigger points create pain throughout the body in predictable patterns characteristic to each muscle, producing discomfort ranging from mild to severe. Trigger point massage increases circulation and oxygenation in the area and often produces instant relief. This dynamic technique has made a huge impact among health professionals and the public alike, becoming an overnight classic in the field of pain relief. The book has sold over 220,000 copies since the release of the first edition in 2001. The second edition is a complete update and includes a new chapter specifically for massage professionals, as well as a chapter on systematic muscle relaxation techniques that can reinforce the therapeutic power of trigger point work.

Mountains Beyond Mountains: The Quest of Dr. Paul Farmer, a Man Who Would Cure the World (Random House Reader's Circle)

This compelling and inspiring book, now in a deluxe paperback edition, shows how one person can work wonders. In Mountains Beyond Mountains, Pulitzer Prize—winning author Tracy Kidder tells the true story of a gifted man who loves the world and has set out to do all he can to cure it.

In medical school, Paul Farmer found his life’s calling: to cure infectious diseases and to bring the lifesaving tools of modern medicine to those who need them most. Kidder’s magnificent account takes us from Harvard to Haiti, Peru, Cuba, and Russia as Farmer changes minds and practices through his dedication to the philosophy that “the only real nation is humanity.” At the heart of this book is the example of a life based on hope and on an understanding of the truth of the Haitian proverb “Beyond mountains there are mountains”–as you solve one problem, another problem presents itself, and so you go on and try to solve that one too.

“Mountains Beyond Mountains unfolds with a force of gathering revelation,” says Annie Dillard, and Jonathan Harr notes, “[Paul Farmer] wants to change the world. Certainly this luminous and powerful book will change the way you see it.”

Rapid Review Pathology: With STUDENT CONSULT Online Access

Get the most from your study time...and experience a realistic USMLE simulation! Rapid Review Pathology, by Edward F. Goljan, MD, makes it easy for you to master all of the pathology material covered on the USMLET Step 1 Exam. It combines an outline-format review of key concepts with over 400 hundred USMLE-style practice questions - online - that give you all the practice you need to succeed!

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  High-yield margin notes: Key content that is most likely to appear on the exam is reinforced in the margin notes.



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  Visual elements: Full-color photographs are utilized to enhance your study and recognition of key pathology images. Abundant two-color schematics and summary tables enhance your study experience.



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• A minimum of 350 USMLE Step 1-type MCQs: Clinically oriented, multiple-choice questions that mimic the current USMLE format, including high-yield images and complete rationales for all answer options.


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Healing ADD: The Breakthrough Program That Allows You to See and Heal the 6 Types of ADD

Hard, visual data make a compelling case for the existence of attention deficit disorder (ADD) in this pioneering work by Daniel G. Amen, M.D. Using a nuclear medicine technique called "single photon emission computed tomography" (SPECT)--a controversial step, according to some of his peers--Dr. Amen scans patients' brains to identify various abnormalities. From more than 8,000 such studies and more than 12,000 patient evaluations, Dr. Amen concludes that six--not the formerly presumed two--different types of ADD exist. This book encompasses the full spectrum of Dr. Amen's work: from symptom identification to clinical evaluation, to diet and medication recommendations, to everyday strategies for living with ADD (whether the reader is a parent of an ADD child, or has been diagnosed with the disease.)

No stranger to the skepticism surrounding this topic, Dr. Amen begins with a list of dead-on myths (including "ADD is overdiagnosed") and surprising facts ("Many people with ADD are never hyperactive"). From this intriguing beginning flows a highly readable chapter on the signs and manifestations of ADD in all ages. Dr. Amen's full description of SPECT imaging includes multiple brain scan photos that nicely support his theories. But the most satisfying element of this well-researched presentation occurs in the final half of the book; here, Amen thoroughly explores the biological (diet, exercise, medication), psychological (from personal coaching to psychotherapy), and social support (parenting and school strategies) needed to heal each type of ADD. This book will prove a valuable tool for parents, adult sufferers, and medical professionals seeking practical support for managing this increasingly recognized condition. --Liane Thomas

Using breakthrough diagnostic techniques, Dr. Daniel Amen has discovered that there are six distinct types of ADD (Attention Deficit Disorder), each requiring a different treatment. With recommendations for prescription drugs, nutraceutical therapy, cognitive reprogramming, parenting and educational strategies, biofeedback, self-hypnosis and more, this revolutionary approach can lead sufferers of ADD to a normal, fully-functional life.